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Dozens of people have reported seizures after vaping, prompting an investigation into the mysterious reaction

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The FDA said it will begin an investigation into a potential link between the nicotine-based vaping devices and seizures and convulsions. Spencer Platt/Getty
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E-cigarettes have come under scrutiny for their potential contribution to teenage nicotine addiction, as well as for the risk of lethal explosions. Now the Food & Drug Administration (FDA) is investigating whether e-cigarettes have any connection to another potential consequence: seizures.

On Wednesday, the FDA announced in a statement that the agency has received 35 reports of people having seizures following e-cigarette use between 2010 and early 2019. In response, the FDA is beginning an investigation into a potential link between nicotine-based vaping devices and seizures and convulsions.

"While 35 cases may not seem like much compared to the total number of people using e-cigarettes, we are nonetheless concerned by these reported cases. We also recognize that not all of the cases may be reported," the administration's press release said.

In some of the reported seizure cases, the patients had a history of seizures before they started using e-cigarettes. Others had a history of using other substances.

An attendee adds vape juice to his electronic cigarette at the Vape Summit III in Las Vegas, Nevada, in this May 2, 2015 file photo.      REUTERS/David Becker/Files
Existing research has suggested nicotine overuse increases a person's risks for seizures and convulsions.  Thomson Reuters

Existing research has found that nicotine overuse increases a person's risks for seizures and convulsions.

"Seizures can begin only 20-30 minutes after swallowing products containing nicotine," the National Capital Poison Center's website notes.

According to the center, nicotine can also cause nausea, vomiting, and dizziness.

The liquid used in e-cigarettes contains a form of nicotine that is more highly concentrated than the kind smokers inhaled. The nicotine is therefore delivered more directly to the blood stream of e-cig users and at higher concentrations than in traditional cigarettes. This could potentially make it easier for a person to get nicotine poisoning.

Still, the limited information and small number of cases that the FDA has to work with makes it difficult to draw a firm conclusion about any potential association between e-cigarettes and seizure risk.

As part of its investigation, the FDA is asking anyone who has experienced seizures after using e-cigarettes to file a report through the agency's Safety Reporting Portal that details the device manufacturer's name, the device's model, and any symptoms experienced.

"It’s our hope that these public steps to solicit additional reports of adverse events, along with other agency efforts, will allow us to understand whether there’s a connection," the FDA wrote.

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Julia Naftulin
Julia Naftulin is an editor on Business Insider's Special Projects team, where she leads editorial initiatives spanning the business, tech, and lifestyle spaces.She has launched and managed series covering how companies adopt and implement AIthe business of food, the 2026 World Cup, and innovation in supply chain management, as well as projects like the AI Power List.Previously, Julia served a five-year tenure as health reporter at Business Insider, covering general wellness and the intersection of relationships, psychology, and culture.Julia reported on the life of a Wall Street accountant-turned-professional-girlfriend, took readers inside Goop's first cruise, explored the dating industry, and delved into the latest plastic surgery trends. She was also Business Insider's resident relationship advice columnist, penning the now-defunct column Doing It Right.She has held editor roles at Health.com and Dotdash Meredith. Her work has been published in Health magazine and on Time, Apartment Therapy, The Knot, and Bicycling.com.Julia graduated from Syracuse University with a Bachelor of Science in Magazine Journalism. Julia lives in Philadelphia with her dachshund, Gretchen.